What If? The Art of Scenario Thinking for Nonprofits

Gives an overview of scenario thinking customized for a nonprofit audience. Outlines the basic phases of scenario development, and provides examples and advice for putting the process into practice. Includes an annotated bibliography of select readings

Catalyzing Networks for Social Change

Explains how funders can "catalyze" networks to address complex, interconnected issues: weave social ties; access diverse perspectives; openly build and share knowledge; create infrastructure for widespread engagement; and coordinate resources and action

Connected Citizens: The Power, Peril and Potential of Networks

Based on surveys and interviews, explores how network-centric practices will affect citizen engagement and community information, with case studies and scenarios for 2015. Offers grantmakers suggestions, tips, and tools for supporting networks for good

Resilience in 2020

In fall 2018, the S. D. Bechtel, Jr. Foundation, along with fellow funders and the authors of this report, set out to study what it takes for nonprofits to survive and even thrive amid disruption, and to better understand how grantmakers can help grow this resilience. "Resilience" was defined as a nonprofit's ability to respond effectively to change and adapt successfully to new and unforeseen circumstances while staying true to mission. Ultimately, seven characteristics emerged as critical to organizational resilience, presented in the resulting report, Resilience at Work. None of the stressors profiled in the original study reached the magnitude of the multiple and interconnected crises that defined 2020 – the pandemic, the uprising for Black lives and racial justice, the economic downturn, the crescendo of natural disasters. The authors wanted to know: What does it take for nonprofits to be resilient in the face of the profound and far-reaching change and uncertainty that no organization was immune from in 2020? Can nonprofits bounce back better equipped to weather future crises? To find out, the S. D. Bechtel, Jr. Foundation commissioned this update

Resilience at Work: How Nonprofits Adapt to Disruption. How Funders Can Help.

Today and in the future, there is one thing social change leaders can be sure of: they will experience disruption, uncertainty, and significant change. Whether recovering from a hurricane, navigating global health concerns, responding to shifts in public policy, or regrouping after the departure of a top leader, nonprofits that get intentional about cultivating organizational resilience are better at anticipating and adapting to disruption.Resilience is critical for surviving these turbulent times. Nonprofit organizational resilience is the ability to respond effectively to change and adapt successfully to new and unforeseen circumstances while staying true to mission. At their best, resilient nonprofits respond to disruptions as tipping points, rather than tragedies, finding new opportunities to learn, grow, evolve, and, ultimately, better serve their communities.So, what does it take for nonprofits to survive and even thrive amid shocks? This research points to seven crucial characteristics, and surfaces principles and practices for funders who seek to boost grantee resilience

Becoming a Learning Organization is a Journey, Not a Destination

Becoming a learning organization is a long-term commitment — a journey, not a destination. The Walton Family Foundation has been on this journey for several years now. We have had successes, setbacks and detours. Along the way, we learned a lot about what it takes to live into our value of continuously improving through learning and reflection.Our central insight so far: becoming a learning organization requires taking a systems-change view and applying it to our own work. This requires engaging an array of mutually reinforcing levers, ranging from targeted interventions to catalysts for deeper shifts, which together create a broader culture change. While there is no single route to becoming a learning organization, we hope that sharing the foundation's practical experience will help others chart their own paths

Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies

Animal models have contributed significantly to our understanding of the underlying biological mechanisms of Alzheimer's disease (AD). As a result, over 300 interventions have been investigated and reported to mitigate pathological phenotypes or improve behavior in AD animal models or both. To date, however, very few of these findings have resulted in target validation in humans or successful translation to disease-modifying therapies. Challenges in translating preclinical studies to clinical trials include the inability of animal models to recapitulate the human disease, variations in breeding and colony maintenance, lack of standards in design, conduct and analysis of animal trials, and publication bias due to under-reporting of negative results in the scientific literature. The quality of animal model research on novel therapeutics can be improved by bringing the rigor of human clinical trials to animal studies. Research communities in several disease areas have developed recommendations for the conduct and reporting of preclinical studies in order to increase their validity, reproducibility, and predictive value. To address these issues in the AD community, the Alzheimer's Drug Discovery Foundation partnered with Charles River Discovery Services (Morrisville, NC, USA) and Cerebricon Ltd. (Kuopio, Finland) to convene an expert advisory panel of academic, industry, and government scientists to make recommendations on best practices for animal studies testing investigational AD therapies. The panel produced recommendations regarding the measurement, analysis, and reporting of relevant AD targets, th choice of animal model, quality control measures for breeding and colony maintenance, and preclinical animal study design. Major considerations to incorporate into preclinical study design include a priori hypotheses, pharmacokinetics-pharmacodynamics studies prior to proof-of-concept testing, biomarker measurements, sample size determination, and power analysis. The panel also recommended distinguishing between pilot 'exploratory' animal studies and more extensive 'therapeutic' studies to guide interpretation. Finally, the panel proposed infrastructure and resource development, such as the establishment of a public data repository in which both positive animal studies and negative ones could be reported. By promoting best practices, these recommendations can improve the methodological quality and predictive value of AD animal studies and make the translation to human clinical trials more efficient and reliable

Philanthropy and Global Threats: Lessons From an Ambitious Experiment

In 2008, Jeff Skoll set out to test whether a limited-life organization with $100 million and a band of driven and skillful "threat-ologists" could make progress against five of the gravest threats to humanity—climate change, pandemics, water security, nuclear proliferation, and conflict in the Middle East. After spending down the original$100 million gift, the SGTF experiment is now coming to an end. However, Jeff Skoll's philanthropy and commitment to global threats will continue. The work is being reorganized, spun out, and unified with Jeff's core philanthropic enterprise, the Skoll Foundation